This is a substantial and transforming revision of the classic text. This edition features nearly 50 per cent new material written by the next generation of leaders in the field of surgery. Highlights include the latest advances and techniques in transplantation, expanded coverage of surgical oncology, a completely new chapter on trauma written by the leading figure on the subject, and a state-of-the-art review of recent findings concerning systemic and metabolic response to injury. Furthermore, in keeping with the implications of managed care, the latest minimally invasive techniques for the surgical treatment and management of disease have been integrated throughout the text. Lastly, the scientific principles underlying pathophysiology and surgical intervention accompany discussion of surgical diagnosis and management.